Channelling Evolution

How much effect on free metabolite concentrations does channelling have?

It would not be appropriate for me, as convener of this discussion, to express any forcible opinions about the controversial aspects of metabolite channelling. Moreover, as an outsider in the field, or at best a newcomer to it, I realize that in expressing any view at all I run the risk of exposing my ignorance without much illuminating the subject. I shall simply pose a question, therefore, as...

Channelling of hydrothermal fluids during the accretion and evolution of the upper oceanic crust: Sr isotope evidence from ODP Hole 1256D

Quantum-classical simulations of the electronic stopping force and charge on slow heavy channelling ions in metals.

By simulating the passage of heavy ions along open channels in a model crystalline metal using semi-classical Ehrenfest dynamics we directly investigate the nature of non-adiabatic electronic effects. Our time-dependent tight-binding approach incorporates both an explicit quantum mechanical electronic system and an explicit representation of a set of classical ions. The coupled evolution of the...

Metabolic control analysis of de novo sunflower fatty acid biosynthesis.

We have obtained a simulation of the final steps of de novo fatty acid biosynthesis in sunflower control line RHA-274. For this simulation, we have used data from the evolution of fatty acids during seed formation and from the biochemical characterization of beta-keto-acyl-ACP synthetase II (FASII), stearoyl-ACP desaturase (SAD) and acyl-ACP thioesterase activities and the program GEPASI (based...

Regulation of Fatty Acid Oxidation Kinetic implications of metabolite channelling in /?-oxidation

Introduction Direct transfer of metabolites between consecutive enzymes, or channelling, is a controversial topic, especially if the enzymes do not form a stable complex, i.e. ‘dynamic’ channelling [ 1-41. The level of passion aroused by discussions of metabolite channelling reflects a belief, not always explicitly stated, that if it occurs then it must have major metabolic consequences [ 51. V...

The analysis of metabolite channelling in multienzyme complexes and multifunctional proteins.

Multienzyme complexes and multifunctional proteins may confer a kinetic advantage by channelling reaction intermediates between consecutive enzymes and reducing the transient time for the establishment of steady states. A general means for quantitatively assessing the contribution of channelling to the reduction of pool size and transient time is presented. Restrictions to the kinetic advantage...